Nature built a great system to keep the brain healthy. We harness it.
Microglia can be neuroprotective: they play a key role in supporting brain health.
The focus of our platform is learning how to harness and manipulate these microglia cells to preserve and restore brain health in response to disease and injury.
The Modulo Platform
Our end-to-end platform combines microglia cell models and advanced machine learning to study the neuroimmune system.
First, we turn patient cells into functional microglia – at scale.
This lets us capture similarities and differences between patients to identify treatments that will be broadly applicable.
Then we use models of the neuroimmune system to see microglia in action.
We test microglia in a variety of models, including a “triculture” model with microglia, astrocytes, and neurons. We can rapidly test different states, genes, or therapeutic candidates to observe cellular behaviors and other measurements of interest.
Microglia behavior is complex. We use machine learning to break it down.
Our cutting-edge machine learning helps us understand microglia by synthesizing experimental results from diffrent models of the neuroimmune system.
We ask questions like: What biological targets influence microglia and shift them into different states? How do microglia in specific states influence disease? How can microglia protect the brain? What neurotoxic outcomes occur when microglia behavior is changed?
To find drugs that treat disease through microglial neuroprotection.
With our insights into microglia and its impact on neuroprotection, we find drugs to help patients with neurological conditions.
Then we use models of the neuroimmune system to see microglia in action.
We test microglia in a variety of models, including a “triculture” model with microglia, astrocytes, and neurons. We can rapidly test different states, genes, or therapeutic candidates to observe cellular behaviors and other measurements of interest.
Microglia behavior is complex. We use machine learning to break it down.
Our cutting-edge machine learning platform helps us understand microglia by synthesizing experimental results from different models of the neuroimmune system.
We ask questions like: What biological targets influence microglia and shift them into different states? How do microglia in specific states influence disease? How can microglia protect the brain? What neurotoxic outcomes occur when microglia behavior is changed?
To find neuroprotective drugs.
With our insights into microglia and their impact on neuroprotection, we find drugs to help patients with neurological conditions.
