The brain has unique immune cells that offer hope for new treatments. They’re called Microglia.
Microglia are key regulators of the nervous system - protecting, maintaining, eliminating, and repairing neurons in order to keep a brain healthy. This capacity for neuroprotection makes them ideal tools for therapeutic intervention.
Studying neuroprotective microglia
Microglia exhibit a variety of behaviors in different situations and can have beneficial, toxic, or neutral impact on the brain. Our technology finds microglial behaviors that support and restore brain health.
Combining models of the neuroimmune system
Models are noisy and never fully represent disease progression. That’s why we look for common signals between different models of the neuroimmune system when understanding microglial behaviors and how to modify them.
Reprogramming microglia to treat patients
We develop drugs that enhance neuroimmune system to treat neurological conditions.
Our Hybrid Approach
Our full-stack team of scientists and engineers combine deep experience in stem cell engineering, neurobiology, multiomics, and machine learning.
Rapidly generate human microglia-centered neuroimmune microenvironments with neurons and astrocytes
from stem cells.
We use multiple complementary models of the neuroimmune system to separate signal from noise.
CRISPR and single cell techniques are used to manipulate and measure the neuroimmune system in cell models and from patient samples.
Discover cell fingerprints, functional biomarkers, optimal experiments, and biological relationships.
